Depending on whom you ask, this might be any of several games. In my opinion, the most difficult poker game to play is defined as one where good players have a large edge over new players, playing drowsy, drunk, or distracted are the most devastating, and the game is regularly played at very high stakes, like in Bobby’s Room at the Bellagio.
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The most mainstream game that most accurately fits these three categories is Deuce to Seven Triple Draw. In Deuce to Seven, the weakest hand wins. Triple Draw is a form of draw poker where players are dealt five cards and have a chance to discard three times during the hand. In Deuce to Seven, straights and flushes count against your hand. The strongest hand is 2-3-4-5-7 (hence the name of the game), and the weakest hand is a made flush. A ten-high hand is weaker than a nine-high hand, regardless of the other four cards in the hand.
Because there are no community cards, bluffing and reading bluffs requires a lot more concentration. Because the winning hand is sometimes a ten-high, but other times a seven-high loses, reading the strength of your opponents hand takes a great deal of skill. For all of these reasons, deuce-to-seven triple draw is definitely one of the hardest poker games.
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